Anthony Mackie is Takeshi Kovacs, taking over the role from Joel Kinnaman.
- Anthony Mackie as Takeshi Kovacs: A former Protectorate CTAC soldier who became a revolutionary Envoy, and then a mercenary for hire, Kovacs swears allegiance to no man or woman except one: Quellcrist Falconer. His undying quest to reconnect with her spans multiple centuries, planets and sleeves.
- Renee Elise Goldsberry as Quellcrist Falconer: A fierce revolutionary leader with a deep bond to Takeshi Kovacs, Quell is driven by her desire to reset the balance between life and death.
- Chris Conner as Poe: A centuries-old, highly-evolved A.I. and loyal companion to Takeshi Kovacs, Poe strives to understand what it means to be human.
- Simone Missick is Trepp: An expert bounty hunter, Trepp is known for her ability to track down anyone in the Settled Worlds, for the right price.
- Dina Shihabi is Dig 30: An out-of-work A.I. programmed to assist human archeologists, Dig finds a new purpose when she meets Poe.
- Torben Liebrecht as Colonel Ivan Carrera: The dogged leader of a Protectorate Special Forces unit known as the “Wedge,” Colonel Carrera is on the hunt for Takeshi Kovacs.
- James Saito is Tanaseda Hideki: A centuries-old Yakuza boss, Tanaseda controls organized crime on the planet of Harlan’s World and shares a history with Takeshi Kovacs.
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